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1

Chemical warfare agent NOVICHOK - mini-review of available data

Nepovimova, Eugenie, Kuca, Kamil

Journal:

Food and Chemical Toxicology

Year:

2018

Language:

english

File:

PDF, 903 KB

english, 2018

2

Handbook of Toxicology of Chemical Warfare Agents || Novichoks

Nepovimova, Eugenie

Year:

2020

File:

PDF, 476 KB

2020

3

Mechanism of cyclosporine A nephrotoxicity: Oxidative stress, autophagy, and signalings

Wu, Qinghua, Wang, Xu, Nepovimova, Eugenie, Wang, Yun, Yang, Hualin, Kuca, Kamil

Journal:

Food and Chemical Toxicology

Year:

2018

Language:

english

File:

PDF, 2.43 MB

english, 2018

4

The history of poisoning: from ancient times until modern ERA

Nepovimova, Eugenie, Kuca, Kamil

Journal:

Archives of Toxicology

Year:

2018

Language:

english

File:

PDF, 4.26 MB

english, 2018

5

Plant Fortification of the Diet for Anti-Ageing Effects: A Review

Dhanjal, Daljeet Singh, Bhardwaj, Sonali, Sharma, Ruchi, Bhardwaj, Kanchan, Kumar, Dinesh, Chopra, Chirag, Nepovimova, Eugenie, Singh, Reena, Kuca, Kamil

Journal:

Year:

2020

File:

PDF, 1.01 MB

2020

6

Mycorrhizal inoculation impact on Acorus calamus L. - An ethnomedicinal plant of western Himalaya and its in silico studies for anti-inflammatory potential

Verma, Rachna, Kumar, Dinesh, Nagraik, Rupak, Sharma, Avinash, Tapwal, Ashwani, Puri, Sunil, Kumar, Harsh, Kumari, Amita, Nepovimova, Eugenie, Kuca, Kamil

Journal:

Journal of Ethnopharmacology

Year:

2021

File:

PDF, 6.08 MB

2021

7

Prolyl oligopeptidase and its role in the organism: attention to the most promising and clinically relevant inhibitors

Babkova, Katerina, Korabecny, Jan, Soukup, Ondrej, Nepovimova, Eugenie, Jun, Daniel, Kuca, Kamil

Journal:

Future Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.81 MB

english, 2017

8

Trichothecenes: immunomodulatory effects, mechanisms, and anti-cancer potential

Wu, Qinghua, Wang, Xu, Nepovimova, Eugenie, Miron, Anca, Liu, Qianying, Wang, Yun, Su, Dongxiao, Yang, Hualin, Li, Li, Kuca, Kamil

Journal:

Archives of Toxicology

Year:

2017

Language:

english

File:

PDF, 4.42 MB

english, 2017

9

Interaction of Synthesized Nitrogen enriched Graphene Quantum Dots with Novel Anti-Alzheimer’s Drugs: Spectroscopic Insights

Sharma, Srishti, Singh, Namrata, Nepovimova, Eugenie, Korabecny, Jan, Kuca, Kamil, Satnami, Manmohan L., Ghosh, Kallol K.

Journal:

Journal of Biomolecular Structure and Dynamics

Year:

2019

Language:

english

File:

PDF, 2.17 MB

english, 2019

10

Flower-Based Green Synthesis of Metallic Nanoparticles: Applications beyond Fragrance

Kumar, Harsh, Bhardwaj, Kanchan, KuÄa, Kamil, Kalia, Anu, Nepovimova, Eugenie, Verma, Rachna, Kumar, Dinesh

Journal:

Year:

2020

File:

PDF, 910 KB

2020

11

Phenytoin â An anti-seizure drug: Overview of its chemistry, pharmacology and toxicology

Patocka, Jiri, Wu, Qinghua, Nepovimova, Eugenie, Kuca, Kamil

Journal:

Food and Chemical Toxicology

Year:

2020

File:

PDF, 710 KB

2020

12

Digoxin: Pharmacology and toxicologyâA review

Patocka, Jiri, Nepovimova, Eugenie, Wu, Wenda, Kuca, Kamil

Journal:

Environmental Toxicology and Pharmacology

Year:

2020

File:

PDF, 2.35 MB

2020

13

Cannabis Constituents and Acetylcholinesterase Interaction: Molecular Docking, In Vitro Studies and Association with CNR1 rs806368 and ACHE rs17228602

Furqan, Tiyyaba, Batool, Sidra, Habib, Rabia, Shah, Mamoona, Kalasz, Huba, Darvas, Ferenc, Kuca, Kamil, Nepovimova, Eugenie, Batool, Sajida, Nurulain, Syed M

Journal:

Year:

2020

File:

PDF, 1.89 MB

2020

14

Adjunct use of honey in diabetes mellitus: A consensus or conundrum?

Sharma, Rohit, Martins, NatÃ¡lia, Chaudhary, Ashun, Garg, Neha, Sharma, Vineet, Kuca, Kamil, Nepovimova, Eugenie, Tuli, Hardeep Singh, Bishayee, Anupam, Chaudhary, Anand, Prajapati, Pradeep Kumar

Journal:

Trends in Food Science & Technology

Year:

2020

File:

PDF, 4.70 MB

2020

15

Malus domestica: A Review on Nutritional Features, Chemical Composition, Traditional and Medicinal Value

Patocka, Jiri, Bhardwaj, Kanchan, Klimova, Blanka, Nepovimova, Eugenie, Wu, Qinghua, Landi, Marco, Kuca, Kamil, Valis, Martin, Wu, Wenda

Journal:

Year:

2020

File:

PDF, 1.60 MB

2020

16

Fruit Extract Mediated Green Synthesis of Metallic Nanoparticles: A New Avenue in Pomology Applications

Kumar, Harsh, Bhardwaj, Kanchan, Dhanjal, Daljeet Singh, Nepovimova, Eugenie, Èen, Fatih, Regassa, Hailemeleak, Singh, Reena, Verma, Rachna, Kumar, Vinod, Kumar, Dinesh, Bhatia, Shashi Kant, KuÄa, K

Journal:

International Journal of Molecular Sciences

Year:

2020

File:

PDF, 2.11 MB

2020

17

Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine—new tacrine derivate with cholinergic properties

Jan Korabecny, Kamil Musilek, Filip Zemek, Anna Horova, Ondrej Holas, Eugenie Nepovimova, Veronika Opletalova, Jana Hroudova, Zdenek Fisar, Young-Sik Jung, Kamil Kuca

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 535 KB

english, 2011

18

Multitarget Drug Design Strategy: Quinone–Tacrine Hybrids Designed To Block Amyloid-β Aggregation and To Exert Anticholinesterase and Antioxidant Effects

Nepovimova, Eugenie, Uliassi, Elisa, Korabecny, Jan, Peña-Altamira, Luis Emiliano, Samez, Sarah, Pesaresi, Alessandro, Garcia, Gregory E., Bartolini, Manuela, Andrisano, Vincenza, Bergamini, Christian

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.86 MB

english, 2014

19

Design, synthesis and in vitro testing of 7-methoxytacrine-amantadine analogues: a novel cholinesterase inhibitors for the treatment of Alzheimer’s disease

Spilovska, Katarina, Korabecny, Jan, Horova, Anna, Musilek, Kamil, Nepovimova, Eugenie, Drtinova, Lucie, Gazova, Zuzana, Siposova, Katarina, Dolezal, Rafael, Jun, Daniel, Kuca, Kamil

Journal:

Medicinal Chemistry Research

Year:

2015

Language:

english

File:

PDF, 702 KB

english, 2015

20

Tacrine – Trolox Hybrids: A Novel Class of Centrally Active, Non-Hepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity

Nepovimova, Eugenie, Korabecny, Jan, Dolezal, Rafael, Babkova, Katerina, Ondrejicek, Ales, Jun, Daniel, Sepsova, Vendula, Horova, Anna, Hrabinova, Martina, Soukup, Ondrej, Bukum, Neslihan, Jost, Petr,

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 4.16 MB

english, 2015

21

P.5.a.002 Therapeutic effect of novel 7-methoxytacrine-donepezil like hybrids on cognitive deficit in rats – a potentiality for Alzheimer's disease treatment

Kassa, J., Korabecny, J., Nepovimova, E., Misik, J.

Journal:

European Neuropsychopharmacology

Year:

2015

Language:

english

File:

PDF, 81 KB

english, 2015

22

Effects of novel tacrine-related cholinesterase inhibitors in the reversal of 3-quinuclidinyl benzilate-induced cognitive deficit in rats – is there a potential for Alzheimer's disease treatment?

Misik, Jan, Korabecny, Jan, Nepovimova, Eugenie, Kracmarova, Alzbeta, Kassa, Jiri

Journal:

Neuroscience Letters

Year:

2015

Language:

english

File:

PDF, 531 KB

english, 2015

23

An HPLC-MS method for the quantification of new acetylcholinesterase inhibitor PC 48 (7-MEOTA-donepezil like compound) in rat plasma: Application to a pharmacokinetic study

Mzik, Martin, Korabecny, Jan, Nepovimova, Eugenie, Voříšek, Viktor, Palička, Vladimir, Kuca, Kamil, Zdarova Karasova, Jana

Journal:

Journal of Chromatography B

Year:

2016

Language:

english

File:

PDF, 479 KB

english, 2016

24

7-Methoxytacrine – 4-Pyridinealdoxime Hybrid as Novel Prophylactic Agent with Reactivation Properties in Organophosphate Intoxications

Nepovimova, Eugenie, Korabecny, Jan, Dolezal, Rafael, Nguyen, Thuy Duong, Jun, Daniel, Soukup, Ondrej, Pasdiorova, Marketa, Jost, Petr, Muckova, Lubica, Malinak, David, Gorecki, Lukas, Musilek, Kamil,

Journal:

Toxicology Research

Year:

2016

Language:

english

File:

PDF, 591 KB

english, 2016

25

SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides

Gorecki, Lukas, Korabecny, Jan, Musilek, Kamil, Malinak, David, Nepovimova, Eugenie, Dolezal, Rafael, Jun, Daniel, Soukup, Ondrej, Kuca, Kamil

Journal:

Archives of Toxicology

Year:

2016

Language:

english

File:

PDF, 1.33 MB

english, 2016

26

Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment

Gazova, Zuzana, Soukup, Ondrej, Sepsova, Vendula, Siposova, Katarina, Drtinova, Lucie, Jost, Petr, Spilovska, Katarina, Korabecny, Jan, Nepovimova, Eugenie, Fedunova, Diana, Horak, Martin, Kaniakova,

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Year:

2016

Language:

english

File:

PDF, 1.86 MB

english, 2016

27

Tetroxime: reactivation potency – in vitro and in silico study

Kuca, K., Korabecny, J., Dolezal, R., Nepovimova, E., Soukup, O., Gorecki, L., Musilek, K.

Journal:

Year:

2017

Language:

english

File:

PDF, 789 KB

english, 2017

28

Inhibitors of Acetylcholinesterase Derived from 7-Methoxytacrine and Their Effects on the Choline Transporter CHT1

Kristofikova, Zdenka, Ricny, Jan, Soukup, Ondrej, Korabecny, Jan, Nepovimova, Eugenie, Kuca, Kamil, Ripova, Daniela

Journal:

Dementia and Geriatric Cognitive Disorders

Year:

2017

Language:

english

File:

PDF, 882 KB

english, 2017

29

Synthesis and In Vitro Evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a Cholinesterase Inhibitor with Regard to Alzheimer's Disease Treatment

Korabecny, Jan, Musilek, Kamil, Holas, Ondrej, Nepovimova, Eugenie, Jun, Daniel, Zemek, Filip, Opletalova, Veronika, Patocka, Jiri, Dohnal, Vlastimil, Nachon, Florian, Hroudova, Jana, Fisar, Zdenek, K

Journal:

Year:

2010

Language:

english

File:

PDF, 240 KB

english, 2010

30

The pharmacology of tacrine at N -methyl- d -aspartate receptors

Horak, Martin, Holubova, Kristina, Nepovimova, Eugenie, Krusek, Jan, Kaniakova, Martina, Korabecny, Jan, Vyklicky, Ladislav, Kuca, Kamil, Stuchlik, Ales, Ricny, Jan, Vales, Karel, Soukup, Ondrej

Journal:

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Year:

2017

Language:

english

File:

PDF, 1.10 MB

english, 2017

31

The influence of modulators of acetylcholinesterase on the resistance of mice against soman and on the effectiveness of antidotal treatment of soman poisoning in mice

Kassa, Jiri, Korabecny, Jan, Nepovimova, Eugenie, Jun, Daniel

Journal:

Journal of Applied Biomedicine

Year:

2017

Language:

english

File:

PDF, 346 KB

english, 2017

32

Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016)

Gorecki, Lukas, Korabecny, Jan, Musilek, Kamil, Nepovimova, Eugenie, Malinak, David, Kucera, Tomas, Dolezal, Rafael, Jun, Daniel, Soukup, Ondrej, Kuca, Kamil

Journal:

Expert Opinion on Therapeutic Patents

Year:

2017

Language:

english

File:

PDF, 948 KB

english, 2017

33

Newly developed drugs for Alzheimer’s disease in relation to energy metabolism, cholinergic and monoaminergic neurotransmission

Korábečný, Jan, Nepovímová, Eugenie, Cikánková, Tereza, Špilovská, Katarína, Vašková, Lucie, Mezeiová, Eva, Kuča, Kamil, Hroudová, Jana

Journal:

Year:

2017

Language:

english

File:

PDF, 891 KB

english, 2017

34

Bis-isoquinolinium and bis-pyridinium acetylcholinesterase inhibitors: in vitro screening of probes for novel selective insecticides

Hrabcova, Veronika, Korabecny, Jan, Manyova, Brigita, Matouskova, Lenka, Kucera, Tomas, Dolezal, Rafael, Musilek, Kamil, Gorecki, Lukas, Nepovimova, Eugenie, Kuca, Kamil, Jun, Daniel

Journal:

Year:

2017

Language:

english

File:

PDF, 1.60 MB

english, 2017

35

Intermolecular interactions between DNA and Methamphetamine, Amphetamine, Ecstasy and their major metabolites

Reis, Arthur F.V.F., Gonçalves, Igor L.P., Neto, Abel F.G., Santos, Alberdan S., Kuca, Kamil, Nepovimova, Eugenie, Neto, Antonio M.J.C.

Journal:

Journal of Biomolecular Structure and Dynamics

Year:

2017

Language:

english

File:

PDF, 3.14 MB

english, 2017

36

The New Acetylcholinesterase Inhibitors PC-37 and PC-48 (7-MEOTA-Donepezil-like Compounds): Characterization of Their Metabolites in Human Liver Microsomes; Pharmacokinetics and In Vivo Formation of the Major Metabolites in Rats

Karasova, Jana Zdarova, Mzik, Martin, Hroch, Milos, Korabecny, Jan, Nepovimova, Eugenie, Vorisek, Viktor, Palicka, Vladimir, Kuca, Kamil

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2017

Language:

english

File:

PDF, 1.06 MB

english, 2017

37

Palytoxin congeners

Patocka, Jiri, Nepovimova, Eugenie, Wu, Qinghua, Kuca, Kamil

Journal:

Archives of Toxicology

Year:

2017

Language:

english

File:

PDF, 1.81 MB

english, 2017

38

In vitro effects of newly developed cholinesterase inhibitors and ABAD modulators on mitochondrial respiration

Hroudová, J., Fišar, Z., Korábečny, J., Nepovímová, E., Spilovská, K., Vašková, L., Mezeiová, E., Musílek, K., Kuča, K., Raboch, J.

Journal:

European Neuropsychopharmacology

Year:

2017

Language:

english

File:

PDF, 72 KB

english, 2017

39

Tacrine - tryptophan derivatives – novel agents against the Alzheimer’s disease

Soukup, O., Korabecny, J., Nepovimova, E., Karasova-Zdarova, J., Vales, K., Ricny, J., Jun, D., Kuca, K.

Journal:

Journal of the Neurological Sciences

Year:

2017

Language:

english

File:

PDF, 367 KB

english, 2017

40

The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease

Hepnarova, V., Korabecny, J., Matouskova, L., Jost, P., Muckova, L., Hrabinova, M., Vykoukalova, N., Kerhartova, M., Kucera, T., Dolezal, R., Nepovimova, E., Spilovska, K., Mezeiova, E., Pham, N.L., J

Journal:

European Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.27 MB

english, 2018

41

Profiling donepezil template into multipotent hybrids with antioxidant properties

Mezeiova, Eva, Spilovska, Katarina, Nepovimova, Eugenie, Gorecki, Lukas, Soukup, Ondrej, Dolezal, Rafael, Malinak, David, Janockova, Jana, Jun, Daniel, Kuca, Kamil, Korabecny, Jan

Journal:

Journal of Enzyme Inhibition and Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 3.85 MB

english, 2018

42

A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase

Kuca, Kamil, Musilek, Kamil, Jun, Daniel, Zdarova-Karasova, Jana, Nepovimova, Eugenie, Soukup, Ondrej, Hrabinova, Martina, Mikler, John, Franca, Tanos C. C., Da Cunha, Elaine F. F., De Castro, Alexand

Journal:

BMC Pharmacology and Toxicology

Year:

2018

Language:

english

File:

PDF, 1.17 MB

english, 2018

43

Insights into the Pharmaceuticals and Mechanisms of Neurological Orphan Diseases: Current Status and Future Expectations

Ramalho, Teodorico C., de Castro, Alexandre A., Tavares, Tássia S., Silva, Maria C., Silva, Daniela R., Cesar, Pedro H., Santos, Lucas A., da Cunha, Elaine F.F., Nepovimova, Eugenie, Kuca, Kamil

Journal:

Progress in Neurobiology

Year:

2018

Language:

english

File:

PDF, 1.65 MB

english, 2018

44

Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon

Kuca, Kamil, Jun, Daniel, Junova, Lucie, Musilek, Kamil, Hrabinova, Martina, da Silva, Jorge, Ramalho, Teodorico, Valko, Marian, Wu, Qinghua, Nepovimova, Eugenie, França, Tanos

Journal:

Year:

2018

Language:

english

File:

PDF, 4.13 MB

english, 2018

45

The history of poisoning: from ancient times until modern ERA

Nepovimova, Eugenie, Kuca, Kamil

Journal:

Archives of Toxicology

Year:

2018

File:

PDF, 4.26 MB

2018

46

Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings

Kuca, Kamil, Zdarova Karasova, Jana, Soukup, Ondrej, Kassa, Jiri, Novotna, Eva, Sepsova, Vendula, Horova, Anna, Pejchal, Jaroslav, Hrabinova, Martina, Vodakova, Eva, Jun, Daniel, Nepovimova, Eugenie,

Journal:

Drug Design Development and Therapy

Year:

2018

Language:

english

File:

PDF, 1008 KB

english, 2018

47

Oxime K074 – in vitro and in silico reactivation of acetylcholinesterase inhibited by nerve agents and pesticides

Kuca, Kamil, Musilek, Kamil, Jun, Daniel, Nepovimova, Eugenie, Soukup, Ondrej, Korabecny, Jan, França, Tanos C. C., de Castro, Alexandre A., Krejcar, Ondrej, da Cunha, Elaine F. F., Ramalho, Teodorico

Journal:

Year:

2018

Language:

english

File:

PDF, 2.05 MB

english, 2018

48

7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer’s Disease Treatment

Korabecny, Jan, Andrs, Martin, Nepovimova, Eugenie, Dolezal, Rafael, Babkova, Katerina, Horova, Anna, Malinak, David, Mezeiova, Eva, Gorecki, Lukas, Sepsova, Vendula, Hrabinova, Martina, Soukup, Ondre

Journal:

Year:

2015

Language:

english

File:

PDF, 2.67 MB

english, 2015

49

Comparison of Novel Tacrine and 7-MEOTA Derivatives with Aromatic and Alicyclic Residues: Synthesis, Biological Evaluation and Docking Studies

Korabecny, Jan, Janovec, Ladislav, Musilek, Kamil, Zemek, Filip, Horova, Anna, Nepovimova, Eugenie, Dolezal, Rafael, Opletalova, Veronika, Hroudova, Jana, Fisar, Zdenek, Jung, Young-Sik, Kuca, Kamil

Journal:

Letters in Organic Chemistry

Year:

2013

Language:

english

File:

PDF, 404 KB

english, 2013

50

The Efficacy of Amifostine against Multiple-Dose Doxorubicin-Induced Toxicity in Rats

Jaćević, Vesna, Dragojević-Simić, Viktorija, Tatomirović, Željka, Dobrić, Silva, Bokonjić, Dubravko, Kovačević, Aleksandra, Nepovimova, Eugenie, Vališ, Martin, Kuča, Kamil

Journal:

International Journal of Molecular Sciences

Year:

2018

Language:

english

File:

PDF, 3.12 MB

english, 2018

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